Laboratory properties of cold-adapted influenza B live vaccine strains developed in the US and USSR, and their B/Ann Arbor/1/86 cold-adapted reassortant vaccine candidates
Identifieur interne : 002084 ( Main/Exploration ); précédent : 002083; suivant : 002085Laboratory properties of cold-adapted influenza B live vaccine strains developed in the US and USSR, and their B/Ann Arbor/1/86 cold-adapted reassortant vaccine candidates
Auteurs : G. I. Alexandrova [Russie] ; H. F. Maassab [États-Unis] ; A. P. Kendal [États-Unis] ; T. E. Medvedeva [Russie] ; A. Y. Egorov [Russie] ; A. I. Klimov [Russie] ; N. J. Cox [États-Unis]Source :
- Vaccine [ 0264-410X ] ; 1990.
English descriptors
- Teeft :
- Alexandrova, Animal studies, Attenuated, Attenuated influenza, Attenuated influenza vaccines, Different temperatures, Disease control, Donor strain, Embryonated, Embryonated eggs, Genome composition, High levels, Influenza, Influenza vaccine, Influenza virus, Influenza virus vaccines, Influenza viruses, Kendal, Laboratory properties, Maassab, Major epidemics, Medical sciences, Other genes, Parent virus, Pckc, Phenotype, Primary chick kidney cells, Protein gene, Reassortant, Reassortant virus, Reassortant viruses, Reference strain, Replication, Temperature sensitivity, Vaccine, Vaccine strains, Virus, Wkly epidem, World health organization.
Abstract
Abstract: The adaptation of two influenza B strains (B/Leningrad/14/55 and B/Ann Arbor/1/66) to replication at 25°C is described. Comparison of the two viruses indicates that both also exhibit temperature sensitive phenotypes, although that of the virus B/Leningrad/14/55 is less pronounced. When inoculated into ferrets both viruses replicate well in the trachea, but only the B/Leningrad/14/55 cold-adapted virus replicates in the lungs. This virus exhibited a moderate level of attenuation in the animals, in contrast to the B/Ann Arbor/1/66 cold-adapted virus, which was fully attenuated. Reassortant viruses deriving the surface antigens of the contemporary wild type virus B/Ann Arbor/1/86 and most or all of their other genes, from one or other cold-adapted parent, were virtually indistinguishable from their respective cold-adapted parents. The B/Leningrad/14/55 reassortant was slightly more attenuated than its cold-adapted parent in ferrets. These studies extend knowledge of the properties of viruses used to prepare experimental live influenza B human vaccines.
Url:
DOI: 10.1016/0264-410X(90)90179-P
Affiliations:
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Egorov</name><affiliation wicri:level="1"><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Experimental Medicine, Academy of Medical Sciences of the USSR, Leningrad, 197022</wicri:regionArea><wicri:noRegion>197022</wicri:noRegion></affiliation></author><author><name sortKey="Klimov, A I" sort="Klimov, A I" uniqKey="Klimov A" first="A. I." last="Klimov">A. I. Klimov</name><affiliation wicri:level="1"><country xml:lang="fr">Russie</country><wicri:regionArea>Research Institute for Viral Preparations, Academy of Medical Sciences of the USSR, Moscow, 109088</wicri:regionArea><wicri:noRegion>109088</wicri:noRegion></affiliation></author><author><name sortKey="Cox, N J" sort="Cox, N J" uniqKey="Cox N" first="N. J." last="Cox">N. J. 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Comparison of the two viruses indicates that both also exhibit temperature sensitive phenotypes, although that of the virus B/Leningrad/14/55 is less pronounced. When inoculated into ferrets both viruses replicate well in the trachea, but only the B/Leningrad/14/55 cold-adapted virus replicates in the lungs. This virus exhibited a moderate level of attenuation in the animals, in contrast to the B/Ann Arbor/1/66 cold-adapted virus, which was fully attenuated. Reassortant viruses deriving the surface antigens of the contemporary wild type virus B/Ann Arbor/1/86 and most or all of their other genes, from one or other cold-adapted parent, were virtually indistinguishable from their respective cold-adapted parents. The B/Leningrad/14/55 reassortant was slightly more attenuated than its cold-adapted parent in ferrets. 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Maassab</name></region><name sortKey="Cox, N J" sort="Cox, N J" uniqKey="Cox N" first="N. J." last="Cox">N. J. Cox</name><name sortKey="Kendal, A P" sort="Kendal, A P" uniqKey="Kendal A" first="A. P." last="Kendal">A. P. Kendal</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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